Today, Muybridge is known for his pioneering work on animal locomotion in 1877 and 1878, which used multiple cameras to capture motion in stop-motion photographs, and his zoopraxiscope, a device for projecting motion pictures that pre-dated the flexible perforated film strip used in cinematography.
In 1874 he shot and killed Major Harry Larkyns, his wife's lover, but was acquitted in a jury trial on the grounds of justifiable homicide. He travelled for more than a year in Central America on a photographic expedition in 1875.
In the 1880s, Muybridge entered a very productive period at the University of Pennsylvania in Philadelphia, producing over 100,000 images of animals and humans in motion, capturing what the human eye could not distinguish as separate movements. He spent much of his later years giving public lectures and demonstrations of his photography and early motion picture sequences, traveling back to England and Europe to publicise his work. He also edited and published compilations of his work, which greatly influenced visual artists and the developing fields of scientific and industrial photography. He returned to his native England permanently in 1894, and in 1904, the Kingston Museum, containing a collection of his equipment, was opened in his hometown.