Uno de los más reconocidos fotógrafos americanos, quizás más apreciado en USA que en Europa.
Fue uno de los primeros introductores de la foto en color como medio de expresión. Sus temas son muchas veces banales para así mostrar de otra manera la forma de vida.
In 1976 with the support of John Szarkowski, the influential photography historian, critic, and curator, Eggleston mounted "Color Photographs" a now famous exhibition of his work at the Museum of Modern Art, New York. William Eggleston's Guide, in which Szarkowski called Eggleston's photographs "perfect," accompanied this groundbreaking one-person show that established his reputation as a pioneer of color photography. His subjects were mundane, everyday, often trivial, so that the real subject was seen to be color itself. These images helped establish Eggleston as one of the first non-commercial photographers working in color and inspired a new generation of photographers, as well as filmmakers.